Well...I think the key errors in your post was the "physicality" part you mentioned, and the durability part you didn't.
Brian Urlacher is about the tallest MLB you see out there, but Floyd does have intriguing range and quickness for his length.
There likely has never been a MLB 6'6" or taller, and there are physical reasons for that. I dont think he would last 1/4 season there. It's more likely to find a 5'10" one.
I forgive you OP because of his range and that Brian Urlachers usage...at least this is the right ball club to talk about a Lobo safety in the NFL.
If you flipped this discussion into a limited package or situational scenario, I'd be in for the experiment.